anti-Tyrosinase CAR-T in vivo assay: Melanoma antigen tyrosinase (TYR) is a single membrane-spanning transmembrane glycoprotein with 13% carbohydrate content and possesses tyrosine hydroxylase, and dopa oxidase catalytic activities. Physiologically, TYR functions for the hydroxylation of a monophenol and conversion of an o-diphenol to the corresponding o-quinone, which are the rate-limiting steps of melanin and other pigments production from tyrosine via oxidation. The normal biological process sorts mature TYR into melanosomes in the skin melanocytes with catalytical domain inwards.
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